杨帆博士,中国科学院深圳先进技术研究院生物医药与技术研究所研究员,深圳理工大学特聘教授,博士生导师,国家高层次青年人才。多伦多大学分子遗传学与计算生物学博士,拥有生物科学与数学双学士学位,曾在多伦多大学及斯坦福大学从事博士后研究。主要聚焦于综合运用分子生物学技术与大数据分析算法,深入解析疾病(如传染病、自身免疫病等)的发病机制及其相关免疫反应特征,揭示个体水平上实现病原体识别、免疫记忆和自身免疫调控的精细化机制。作为负责人承担国家自然科学基金优秀青年科学基金项目(海外)、国家重点研发,国自然面上、广东省面上等项目。发表SCI论文20余篇,其中在Nature、Science、Cell、Nature Medicine、Cell Host & Microbe等国际顶级期刊发表论文10余篇,总被引次数超过5700次。
免疫学,计算生物学
1.“Uncovering the dual roles of peripheral immune cells and their connections to brain cells in stroke and post-stroke stages through single-cell sequencing” Zheng Xu, Fan Yang#, Lifang Zheng#, Frontiers in Neuroscience, 2024 Nov. 18:e1443438.
2.“An in silico design of a vaccine against all serotypes of the Dengue virus based on virtual screening of B-Cell and T-Cell epitopes” Hikmat Ullah, Shaukat Ullah, Jinze Li, Fan Yang#, Lei Tan#, Biology, 2024 August. 13(9): p. 681.
3.“Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues” Fan Yang#, Sandra C. A. Nielsen, Ramona A. Hoh, Katharina Röltgen, Oliver Fabian Wirz, Emily Haraguchi, Grace H Jean, Ji-Yeun Lee, Tho D. Pham, Katherine J.L. Jackson, Krishna M. Roskin, Yi Liu, Khoa Nguyen, Rober S. Ohgami, Kari C. Nadeau, Eleanor L. Marshall, Claus U. Niemann, Julie Parsonnet, Scott D. Boyd#. Science, 2021 April. 372(6543): p. 738.
4.“Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2” Sandra C. A. Nielsen*, Fan Yang*, Katherine J. L. Jackson*, Ramona A. Hoh*, Katharina Röltgen, Bryan Stevens, Ji-Yeun Lee, Arjun Rustagi, Angela J. Rogers, Abigail E. Powell, Javaria Najeeb, Ana R. Otrelo-Cardoso, Kathryn E. Yost, Bence Daniel, Howard Y. Chang, Ansuman T. Satpathy, Theodore S. Jardetzky, Peter S. Kim, Taia T. Wang, Benjamin A. Pinsky, Catherine A. Blish#, Scott D. Boyd#, Cell Host & Microbe, 2020 October, 28(4) 516-525.e5.
5. “Quantifying Immune-Based Counterselection of Somatic Mutations” Fan Yang, Dae-Kyum Kim, Hidewaki Nakagawa, Seiya Imoto, Lincoln Stein and Frederick P. Roth, PLoS Genetics, 2019 July, 15(7): e1008227.