中国科学院深圳先进技术研究院副研究员,硕士生导师。欧盟玛丽居里学者,比利时鲁汶大学博士后,欧洲分子生物学会(EMBO)短期基金获得者。分别在南开大学、英国伦敦大学学院和荷兰奈梅亨大学取得学士、硕士和博士学位。与欧洲科研机构合作,致力于3D微环境中的细胞生物力学研究以及新型非线性人工聚合物材料-螺旋聚异腈(PIC)水凝胶的研发、生产与生物医学应用。
细胞-基质力学互作;生物流变学;螺旋聚异腈(PIC)水凝胶的生物医学应用
1. Yuan, H.#*, Liu, K.#*, van Velthoven, M. J., Kumari, J., Bao, Y., Rocha, S., & Kouwer, P. H.* (2025). Fibrous polyisocyanide hydrogels for 3D cell culture applications. Nature Protocols, 1-22. (IF=14.8,共同第一作者&通讯作者)
2. Yuan, H.#*, Liu, K.#, Cóndor, M., Barrasa-Fano, J., Louis, B., Vandaele, J., ... & Rocha, S.* (2023). Synthetic fibrous hydrogels as a platform to decipher cell–matrix mechanical interactions. Proceedings of the National Academy of Sciences, 120(15), e2216934120. (IF=11.1,共同第一作者)
本文被Nature Reviews Bioengineering专题报道:Bakhshandeh, S. (2023). A designer matrix to study cell–ECM interactions. Nature Reviews Bioengineering, 1-1.
3. Liu, K., Wiendels, M., Yuan, H., Ruan, C., & Kouwer, P. H.* (2022). Cell-matrix reciprocity in 3D culture models with nonlinear elasticity. Bioactive Materials, 9, 316-331. (IF=18.9,第一作者,ESI高被引论文)
4. Liu, K., Veenendaal, T., Wiendels, M., Ruiz-Zapata, A. M., van Laar, J., Kyranas, R., Enting, H., van Cranenbroek, B., Koenen, H., Mihaila, S., Oosterwijk, E., Kouwer, P.H.* (2020) Synthetic extracellular matrices as a toolbox to tune stem cell secretome. ACS Applied Materials & Interfaces,12(51), 56723-56730. (IF=9.5,第一作者)
5. Liu, K., Mihaila, S. M., Rowan, A., Oosterwijk, E., & Kouwer, P. H.* (2019). Synthetic extracellular matrices with nonlinear elasticity regulate cellular organization. Biomacromolecules, 20(2), 826-834. (IF=6.2,第一作者)
本文被包括Nature在内的多篇文章相继引用,包括:Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020). Effects of extracellular matrix viscoelasticity on cellular behaviour. Nature, 584(7822), 535-546.
作为第一/通讯作者,在The Proceedings of the National Academy of Sciences(PNAS)、Cell Reports Physical Science、ACS Applied Materials & Interfaces、Bioactive Materials和Biomacromolecules等国际高水平杂志发表论文十余篇,并被Nature Protocols邀稿撰写仿生水凝胶的3D细胞培养标准。