中国科学院深圳先进技术研究院副研究员,硕士生导师。欧盟玛丽居里学者,比利时鲁汶大学博士后,欧洲分子生物学会(EMBO)短期基金获得者。分别在南开大学、英国伦敦大学学院和荷兰奈梅亨大学取得学士、硕士和博士学位。与欧洲科研机构合作,致力于3D微环境中的细胞生物力学研究以及新型非线性人工聚合物材料-螺旋聚异腈(PIC)水凝胶的研发、生产与生物医学应用。
细胞-基质力学互作;生物流变学;螺旋聚异腈(PIC)水凝胶的生物医学应用
1. Yuan, H. #*, Liu, K. #*, van Velthoven, M. J., Jyoti, K., Bao, Y., Rocha, S., & Kouwer, P. H.* (2024), Fibrous polyisocyanide hydrogels for 3D cell culture applications. Nature Protocols, accepted. (共同第一作者&共同通讯作者) 2. Liu, K. #, Vandaele, J. #, Yuan, H., Blank, K. G., Hammink, R., Kouwer, P. H., & Rocha, S. (2024). Structure and applications of PIC-based polymers and hydrogels. Cell Reports Physical Science, 5(2), 101834. (第一作者)
2. Yuan, H. #, Liu, K. #, Cóndor, M., Barrasa-Fano, J., Louis, B., Vandaele, J., ... & Rocha, S. (2023). Synthetic fibrous hydrogels as a platform to decipher cell–matrix mechanical interactions. Proceedings of the National Academy of Sciences, 120(15), e2216934120. (共同第一作者)
3. Liu, K., Wiendels, M., Yuan, H., Ruan, C., & Kouwer, P. H. (2022). Cell-matrix reciprocity in 3D culture models with nonlinear elasticity. Bioactive materials, 9, 316-331. (第一作者,ESI高被引论文)
4. Liu, K., Veenendaal, T., Wiendels, M., Ruiz-Zapata, A. M., van Laar, J., Kyranas, R., Enting, H., van Cranenbroek, B., Koenen, H., Mihaila, S., Oosterwijk, E., Kouwer, P.H. (2020) Synthetic extracellular matrices as a toolbox to tune stem cell secretome. ACS applied materials & interfaces,12(51), 56723-56730. (第一作者)
5.Liu, K., Mihaila, S. M., Rowan, A., Oosterwijk, E., & Kouwer, P. H. (2019). Synthetic extracellular matrices with nonlinear elasticity regulate cellular organization. Biomacromolecules, 20(2), 826-834. (第一作者)
作为第一/通讯作者,在The Proceedings of the National Academy of Sciences(PNAS)、Cell Reports Physical Science、ACS Applied Materials & Interfaces、Bioactive Materials和Biomacromolecules等国际高水平杂志发表论文十余篇,并被Nature Protocols邀稿撰写仿生水凝胶的3D细胞培养标准。