李志腾博士于2020年毕业于中国科学院大学,2020-2021年在恒瑞医药新药研发部门(R&D)任研究员,2021-2024年在美国哥伦比亚大学从事博士后研究。主要研究方向包括靶向病毒的抗体筛选与优化,免疫蛋白分子结构解析以及蛋白药物设计等领域。曾参与由美国国立卫生研究院和比尔及梅琳达·盖茨基金会资助的多个研究项目,其相关研究成果发表在Cell,PNAS, The Lancet Infectious Diseases, Cell Host & Microbe ,iScience等国际权威期刊,论文总引用次数超过2000次。

  病毒免疫学,抗体发现,抗体工程化,蛋白药物设计与优化

  1. Qian Wang# , Zhiteng Li# , Yicheng Guo# , Ian A Mellis# , Sho Iketani, Michael Liu, Jian Yu, Riccardo Valdez, Adam S Lauring, Zhizhang Sheng, Aubree Gordon, Lihong Liu*, David D Ho*. (2023) Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2. iScience. 26, 108254. https://doi.org/10.1016/j.isci.2023.108254

  2. Qian Wang# , Sho Iketani# , Zhiteng Li# , Liyuan Liu# , Yicheng Guo# , Yiming Huang, Anthony D Bowen, Michael Liu, Maple Wang, Jian Yu, Riccardo Valdez, Adam S Lauring, Zizhang Sheng, Harris H Wang, Aubree Gordon, Lihong Liu*, David D Ho*. (2023) Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants. Cell, 186(2), 279-286. https://doi.org/10.1016/j.cell.2022.12.018  

  3. Qian Wang# , Zhiteng Li# , Jerren Ho, Yicheng Guo, Andre Yanchen Yeh, Hiroshi Mohri, Michael Liu, Maple Wang, Jian Yu, Jayesh G Shah, Jennifer Y Chang, Favio Herbas, Michael T Yin, Magdalena E Sobieszczyk, Zizhang Sheng, Lihong Liu*, David D Ho*. (2022) Resistance of SARS-CoV-2 omicron subvariant BA. 4.6 to antibody neutralisation. The Lancet Infectious Diseases, 22(12), 1666-1668. https://doi.org/10.1016/S1473-3099(22)00694-6

  4. Ruchao Peng# , Zhiteng Li# , Ying Xu# , Shaoshuai He, Qi Peng, Lian-ao Wu, Ying Wu, Jianxun Qi, Peiyi Wang, Yi Shi*, and George F. Gao*. (2019) Structural insight into multistage inhibition of CRISPRCas12a by AcrVA4. Proceedings of the National Academy of Sciences, 116(38):18928-18936. https:// doi.org/10.1073/pnas.1909400116

  5. Qian Wang# , Sho Iketani# , Zhiteng Li, Yicheng Guo, Andre Yanchen Yeh, Michael Liu, Jian Yu, Zizhang Sheng, Yaoxing Huang, Lihong Liu*, David D Ho*. (2022) Antigenic characterization of the SARS-CoV2 Omicron subvariant BA. 2.75. Cell Host & Microbe, 30(11), 1512-1517. https://doi.org/10.1016/j.chom.2022.09.002