中国科学院昆明动物研究所博士（2004-2010），美国密歇根大学医学院博士后（2014-2021）。2021年入职深圳理工大学和中国科学院深圳先进技术研究院，并陆续获得深圳市海外高层次人才“孔雀计划”B类人才和广东省引进青年拔尖人才支持。曾先后主持国家自然科学面上基金和青年基金项目，中国科学院“西部之光”人才项目以及863计划子课题项目。曾荣获2016年美国免疫学年会摘要奖和2019年Moses Gunn会议最佳墙报奖。迄今为止累计发表论文33篇，引用超过4300多次，H指数为21（Google Scholar）。其中以第一作者或通讯作者在Science Immunology, Nature Reviews Cancer和JCI insights等SCI杂志上共发表论文15篇，并在Nature， Cancer cell和JCI等杂志参与发表论文18篇。参与出版学术著作1部，申请及授权中国发明专利5项。

自噬参与抗肿瘤免疫反应的机制、巨噬细胞调节肿瘤免疫逃逸的机理、抗肿瘤免疫相关小分子药物的筛选及机制研究等。

1. Xia H, Green DR*, and Zou W*. Autophagy in tumour immunity and therapy (Review). Nat Rev Cancer. 2021;21:281–297.

2. Xia H, Li S, Li X, Wang W, Bian Y, Wei S, Grove S, Wang W, Vatan L, Liu JR, McLean K, Rattan R, Munkarah AR, Guan JL, Kryczek I, Zou W*. Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis. JCI insight. 2020;5(18):141115.

3. Xia H#, Wang W#, Crespo J, Kryczek I, Li W, Wei S, Bian Z, Maj T, He M, Liu RJ, He Y, Rattan R, Munkarah A, Guan JL, Zou W*. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Sci Immunol. 2017;2(17).eaan4631.

4. Xia H#, He B#, Wang C, Zhang H, Ge G, Zhang Y, Lv L, Jiao J, Chen C*. PTEN/PIK3CA genes are frequently mutated in spontaneous and medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumours of tree shrews. Eur J Cancer. 2014;50(18):3230-42.

5. Xia H, Wang C, Chen W, Zhang H, Chaudhury L, Zhou Z, Liu R, Chen C*. Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer. J Biol Chem. 2013;288(37):26731-40.

1. Choi JE, Qiao Y, Kryczek I, Yu J, Gurkan J, Bao Y, Gondal M, Tien JC, Maj T, Yazdani S, Parolia A, Xia H, Zhou J, Wei S, Grove S, Vatan L, Lin H, Li G, Zheng Y, Zhang Y, Cao X, Su F, Wang R, He T, Cieslik M, Green MD, Zou W*, Chinnaiyan AM*. PIKfyve, expressed by CD11c-positive cells, controls tumor immunity. Nat Commun. 2024 28;15(1):5487.

2. Chen X, Lu Z, Xiao J, Xia W, Pan Y, Xia H, Chen YH*, Zhang H*. Small-Molecule Inhibitors of TIPE3 Protein Identified through Deep Learning Suppress Cancer Cell Growth In Vitro. Cells. 2024;13(9):771.

3. Pitter MR, Kryczek I, Zhang H, Nagarsheth N, Xia H, Wu Z, Tian Y, Okla K, Liao P, Wang W, Zhou J, Li G, Lin H, Vatan L, Grove S, Wei S, Li Y, Zou W*. PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages. Cell Rep. 2024;43(3):113942.

4. Yang L, Liu J, Guo W, Zheng Z, Xu Y, Xia H*, Xiao T*. Insights into the multi-chromosomal mitochondrial genome structure of the xero-halophytic plant Haloxylon Ammodendron (C.A.Mey.) Bunge ex Fenzl. BMC genomics. 2024;25 (1), 123.

5. Chen X, Li Y, Xia H*, Chen YH*. Monocytes in Tumorigenesis and Tumor Immunotherapy. Cells. 2023;12 (13), 1673

6. Xia H*, Chen YH*. How sugar instigates macrophages to be evils in tumor. Cellular & Molecular Immunology. 2022; 19 (12), 1325-1327.

7. Zhang Y, Ouyang D, Chen YH, Xia H*. Peritoneal resident macrophages in tumor metastasis and immunotherapy. Front Cell Dev Biol. 2022;10:948952.

8. Li F, Liang H, You H, Xiao J, Xia H, Chen X, Huang M, Cheng Z, Yang C, Liu W, Zhang H, Zeng L, Wu Y, Ge F, Li Z, Zhou W, Wen Y, Zhou Z, Liu R, Jiang D, Xie N, Liang B, Liu Z, Kong Y, Chen C*. Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis. Signal Transduct Target Ther. 2022;7(1):264.

9. Xia H, Green DR*, and Zou W*. Autophagy in tumour immunity and therapy (Review). Nat Rev Cancer. 2021;21:281–297.

10. Lin H, Kryczek I, Li S, Green MD, Ali A, Hamasha R, Wei S, Vatan L, Szeliga W, Grove S, Li X, Li J, Wang W, Yan Y, Choi JE, Li G, Bian Y, Xu Y, Zhou J, Yu J, Xia H, Wang W, Alva A, Chinnaiyan AM, Cieslik M, Zou W*. Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance. Cancer Cell. 2021;39(4):480-493.e6.

11. Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu Z, Zhang L, Czerwonka A, Pawłowska A, Xia H, Li J, Liao P, Yu J, Vatan L, Szeliga W, Wei S, Grove S, Liu JR, McLean K, Cieslik M, Chinnaiyan A, Zgodziński W, Wallner G, Wertel I, Okła K, Kryczek I, Lyssiotis CA, Zou W*. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. 2020;585(7824):277-282.

12. Xia H, Li S, Li X, Wang W, Bian Y, Wei S, Grove S, Wang W, Vatan L, Liu JR, McLean K, Rattan R, Munkarah AR, Guan JL, Kryczek I, Zou W*. Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis. JCI insight. 2020;5(18):141115.

13. Wang W, Green M, Choi J, Gijón M, Kennedy P, Johnson J, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence T, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan T, Chinnaiyan A, Zou W*. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569(7755):270-274.

14. Li W, Tanikawa T, Kryczek I, Xia H, Li G, Wu K, Wei S, Zhao L, Vatan L, Wen B, Shu P, Sun D, Kleer C, Wicha M, Sabel M, Tao K, Wang G, Zou W*. Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer. Cell Metab. 2018;28(1):87-103.e6.

15. Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, Xiao J, Chen X, Xia H, Wu Y, Zhou Z, Guo X, Hu C, Yang C, Cheng X, Chen C*, Qi X*. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128(9):4148-4162.

16. Xia H#, Wang W#, Crespo J, Kryczek I, Li W, Wei S, Bian Z, Maj T, He M, Liu RJ, He Y, Rattan R, Munkarah A, Guan JL, Zou W*. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Sci Immunol. 2017;2(17).eaan4631.

17. Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, Kobberup S, Zou W, Lin JD*. Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J Clin Invest. 2017;127(12):4449-4461.

18. Ge G#, Xia H#, He B, Zhang H, Liu W, Shao M, Wang C, Xiao J, Ge F, Li F, Li Y, Chen C*. Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution. Int J Cancer. 2016;138(3):642-51.

19. Qin J, Zhou Z, Chen W, Wang C, Zhang H, Ge G, Shao M, You D, Fan Z, Xia H, Liu R, Chen C*. BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5. Nat Commun. 2015;6:8471.

20. Xia H#, He B#, Wang C, Zhang H, Ge G, Zhang Y, Lv L, Jiao J, Chen C*. PTEN/PIK3CA genes are frequently mutated in spontaneous and medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumours of tree shrews. Eur J Cancer. 2014;50(18):3230-42.

21. Xia H, Wang C, Chen W, Zhang H, Chaudhury L, Zhou Z, Liu R, Chen C*. Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer. J Biol Chem. 2013;288(37):26731-40.

22. Xia H, Wang C, Zhang H, He B, Jiao J, Chen C*. Characterization of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis). Zoological Research. 2012, 33(1): 55-59.

23. Xia H, Ma J, Zhang G, Han J, Wang J, Zheng Y*. Effect of plasma viremia on apoptosis and immunophenotype of dendritic cells subsets in acute SIVmac239 infection of Chinese rhesus macaques. PLoS One. 2011, 6(12):e29036.

24. Xia H, Chen C*. Progress of non-human primate animal models of cancers (Review), Zoological Research. 2011, 32(1): 70-80.

25. Xia H, Zhang G, Ma J, Dai Z, Li S, Han J, Zheng Y*. Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques. Retrovirology. 2010, 7:102.

26. Xia H, Zhang G, Zheng Y*. Roles of Dendritic Cell in Disease Progression of AIDS Primate Models (Review). Zoological Research. 2010, 31(1):57-65.

27. Xia H, Liu H, Zhang G, Zheng Y*. Phenotype and function of monocyte-derived dendritic cells from chinese rhesus macaques. Cell Mol Immunol. 2009, 6(3):159-165.

28. Xia H, Zhang G, Wang R, Zheng Y*. The influence of age and sex on the cell counts of peripheral blood leukocyte subpopulations in Chinese rhesus macaques. Cell Mol Immunol. 2009, 6(6):433-440.