研究员，博士生导师，深圳市孔雀计划人才，中国细胞生物学学会、中国生物化学学会会员，深圳市分子生物学学会理事，广东省纳米医药重点实验室副主任。在Nature Nanotechnology，Nature Chemical Biology, Cell Research，JACS，PNAS等发表研究论文50余篇，是Nature Nanotechnology、Nature Communication等杂志的特邀评审专家，承担科技部重大研究计划、国家自然科学基金面上和广东省重点项目20余项，授权发明专利8项。

肿瘤发生机制和抗肿瘤药物研发，包括肿瘤细胞分裂机制、抗肿瘤天然多肽药物、和抗肿瘤纳米技术研发。

1.    Binghua Cheng#, Meiqing Li#, Jiwei Zheng#, Ruijing Liang, Li Ding, Yanyan Li, Wenli Shi, Long Meng, Ke Liu, Lintao Cai*, Ximing Shao*, Lijing Fang*， Hongchang Li*. (2025) Chemically Engineered Antibodies for Autophagy-based Receptor Degradation. Nature Chemical Biology, DOI: 10.1038/s41589-024-01803-1.
2.    Jiwei Zheng#, Wanyi He#, Jing Li#, Xuejia Feng, Yanyan Li, Binghua Cheng, Yimin Zhou, Meiqing Li, Ke Liu, Ximing Shao, Jianchao Zhang, Hongchang Li*, Liang Chen*, Lijing Fang*. (2022) Bifunctional Compounds as Molecular Degraders for Integrin-facilitated Targeted Protein Degradation. JACS, 7;144(48):21831-21836.
3.    Guofang Zhang#, Yalin Cong#, Feng-Liang Liu#, Jiufeng Sun#, Jiantian Zhang, Guoli Cao, Lingqiang Zhou, Wenjie Yang, Qingle Song, Fangjun Wang, Ke Liu, Jing Qu, Jing Wang, Min He, Shun Feng, Didar Baimanov, Wei Xu, Rong-Hua Luo, Xin-Yan Long, Shumin Liao, Yunping Fan, Yufeng Li, Bai Li, Ximing Shao, Guocheng Wang, Lijing Fang, Huaiyu Wang, Xue-Feng Yu, Yanzhong Chang, Yuliang Zhao, Liang Li, Peng Yu, Yong-Tang Zheng*, Diana Boraschi, Hongchang Li*, Chunying Chen*, Liming Wang*, Yang Li*. (2022) A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. Nature Nanotechnology, 17(9):993-1003.
4.    Ximing Shao#, Zhihao Ding#, Wenhua Zhou, Yanyan Li, Zhibin Li, Haodong Cui, Xian Lin, Guoli Cao, Binghua Cheng, Haiyan Sun, Meiqing Li, Ke Liu, Shengyong Geng, Wenli Shi, Guofang Zhang, Qingle Song, Liang Chen, Guocheng Wang, Wu Su, Lintao Cai, Lijing Fang, David Tai Leong, Yang Li*, Xue-Feng Yu*,   Hongchang Li*（2021）Intrinsic Bioactivity of Black Phosphorus Nanomaterials on Mitotic Centrosome Destabilization through Suppression of PLK1 Kinase. Nature Nanotechnology, 16, 1150–1160.
5.    Ximing Shao#, Yi Liu#, Qian Yu#, Zhihao Ding, Wenyu Qian, Lei Zhang, Jianchao Zhang, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang Li*, Huashun Li*. (2016) Numb Regulates Vesicular Docking for Homotypic Fusion of Early Endosomes via Membrane Recruitment of Mon1b. Cell Research, 26(5):593-612.

代表性成果包括：在抗肿瘤药物领域，揭示了磷基纳米材料的递送-靶向一体化抗肿瘤机制，并提出肿瘤纳米磷疗理念，为抗肿瘤纳米药物研发提供了全新方向（Nature Nanotechnology，2021，末位通讯）。针对新冠病毒，开发了抑制病毒入侵的广谱抗新冠纳米药物。该药物不仅能够有效抑制病毒对宿主细胞的侵染，而且能够提供长期免疫保护（Nature Nanotechnology，2022，共同通讯）。基于生物大分子跨细胞递送理念，发明了全新细胞膜蛋白靶向降解技术。与现有技术相比，新技术将药物降解剂量降低了约100倍，大大提高了用于药物研发的可行性（Nature Chemical Biology，2025，末位通讯）。